PLOS GENETICS Junio 2010

Último número PLOS GENETICS 20 Junio 2010

Perspective
Understanding Adaptation in Large Populations

Nick Barton offers his Perspective on the study by Karasov and colleagues, who investigate adaptation at a key insecticide resistance locus in Drosophila melanogaster, and show that multiple simple and complex resistance alleles evolved quickly and repeatedly within individual populations.


Featured Research
An Integration of Genome-Wide Association Study and Gene Expression Profiling to Prioritize the Discovery of Novel Susceptibility Loci for Osteoporosis-Related Traits

The authors take advantage of SNP and transcript arrays and integrate GWAS and expression signature profiling relevant to the skeletal system in cellular and animal models to prioritize the discovery of novel candidate genes for osteoporosis-related traits.


siRNA–Mediated Methylation of Arabidopsis Telomeres

The authors analyze chromatin structure and RNA transcription at chromosome termini in Arabidopsis and provide evidence for an siRNA–directed mechanism of chromatin maintenance at telomeres.


Mice with Alopecia, Osteoporosis, and Systemic Amyloidosis Due to Mutation in Zdhhc13, a Gene Coding for Palmitoyl Acyltransferase

This mouse model can be used to investigate mechanisms where improper palmitoylation leads to disease processes and to understand molecular mechanisms underlying human alopecia, osteoporosis, and amyloidosis, and other neurodegenerative diseases caused by protein misfolding and amyloidosis.